Praise be to Allah, and may peace and blessings be upon the Messenger of Allah. To proceed:
Disliking this world and feeling weary of it can have different causes. Some people turn away from it out of longing for what is with Allah and love for the Hereafter. This is not blameworthy if it is accompanied by fulfilling one's duties toward Allah and His servants and striving to do good. Others dislike it because they feel that they have been given less than others, and this may arise from dissatisfaction with Allah's decrees and provisions. Others dislike it because of the many trials and hardships they have experienced in it, even though this world by its nature is a place of trial and action, not a place of permanent comfort.
The prophets and righteous people were tested with the most severe forms of hardship. The Prophet ﷺ was harmed, besieged, and driven out, and a month or two would pass without a fire being lit in his household. Despite this, he remained committed to Allah's command, patient, and seeking reward from Him. Therefore, hardship is not evidence that a person has been abandoned or that his life is without meaning.
Among the most important things that can help you overcome weariness and distress are:
Strengthening your connection with Allah through abundant prayer, supplication, remembrance, seeking forgiveness, and other acts of obedience. Allah, the Most High, says:
﴿Surely, in the remembrance of Allah do hearts find tranquility.﴾ [Ar-Ra'd: 28].
Having a good opinion of Allah and being content with His decree; what Allah decrees for a believer may be good for him, even if its wisdom is hidden from him. A person does not know what lies behind the things he has missed or failed to attain.
Examining yourself and repenting from sins; some distress may be caused by shortcomings and sins, and repentance and seeking forgiveness are among the greatest means of relief.
Addressing real-life problems; if the cause of your weariness is personal or family-related problems, organize your priorities, seek Allah's help, and consult people of knowledge, experience, and righteousness about solving them instead of surrendering to them.
Being patient with trials; hardship is a recurring part of the believer's life and may be a means of expiating sins and raising one's ranks. The Prophet ﷺ said: “The people most severely tested are the prophets, then those closest to them in righteousness, then those closest to them.”
Not surrendering to helplessness and regret; if something has passed you by, do not say, “If such-and-such had happened, then such-and-such would have happened.” Rather, take whatever means you are able to take, seek Allah's help, and say: “Allah has decreed, and whatever He wills, He does.”
Practicing detachment from the adornments of this world without abandoning work; no matter how great its pleasures may be, this world is temporary, while what is with Allah is better and more lasting. Allah, the Most High, says:
﴿And the provision of your Lord is better and more lasting.﴾ [Ta-Ha: 131].
Remember that what is required is not to hate life for its own sake, but rather to make this world a means toward obedience to Allah and attaining the Hereafter, and to continue worshipping, working, and striving for reform until one's appointed time comes. Allah, the Most High, says:
﴿And worship your Lord until certainty comes to you.﴾ [Al-Hijr: 99].
If your weariness has reached the point where you are thinking about harming yourself or persistently wishing for death, do not remain alone with these thoughts. Instead, tell someone you trust and seek the help of a qualified professional immediately, while also turning to Allah and supplicating to Him.
And Allah, the Most High, knows best.